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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Reprod Toxicol. 2021 Nov 25;107:60–68. doi: 10.1016/j.reprotox.2021.11.008

Table 4.

Effect of Pharmaceuticals, Phytochemicals, and Other Chemicals on the In Vitro Migration and Invasion of Extravillous Trophoblasts.

Chemical Concentrations Experimental Model Migration or Invasion Direction of Change Assay Type Ref
Valproate 100–400μM HTR-8/SVneo cells Migration Reduced Wound healing [110]
Thalidomide 100–400μM HTR-8/SVneo cells Migration Reduced Wound healing [110]
Dexamethasone 100–10,000nM HTR-8/SVneo cells Invasion Reduced Spheroid invasion [118]
Δ 9 -Tetrahydrocannabinol 30μM HTR-8/SVneo cells Invasion Reduced Spheroid invasion [118]
Ethyl Alcohol 25mM; 100mM HTR-8/SVneo cells Migration Reduced; Increased Scratch wound [110]
PM2.5 1 120μg/ml HTR-8/SVneo cells Both Reduced Transwell [114]
1

PM: Particulate matter less than 2.5 μm.