Table 2.
MuV-specific humoral and cell-mediated immune outcomes overall and by sex
| Neutralizing Antibody/Cytokine/Chemokine | Overall Response (n = 748) (stim-unstim, pg/ml) Median (25%, 75% IQR) | Sex Female (n = 327) Median (25%, 75% IQR) | Sex Male (n = 421) Median (25%, 75% IQR) | Sex p-value |
|---|---|---|---|---|
| Neutralizing Antibody | 109.8 (43.9, 250.7) | 120.8 (49.7, 297.6) | 98.7 (40.6, 238.0) | 0.038 |
| MIP-1α | 780.6 (267.5, 1917.3) | 561.3 (201.3, 1566.9) | 922.4 (319.2, 2147.9) | 0.000044 |
| TNFα | 53.1 (27.2, 96.7) | 45.2 (25.0, 80.4) | 58.5 (30.0, 107.0) | 0.0003 |
| MIP-1β | 565.8 (263.2, 1097.8) | 494.7 (228.7, 958.9) | 618.1 (304.0, 1199.1) | 0.001 |
| IL-6 | 572.8 (320.6, 1011.1) | 519.0 (306.5, 874.1) | 603.6 (333.1, 1088.3) | 0.028 |
| IFNγ | 109.0 (42.4, 246.1) | 96.7 (37.8, 217.2) | 119.1 (47.3, 262.4) | 0.031 |
| IL-1β | 15.6 (6.3, 38.2) | 13.6 (5.6, 34.8) | 17.4 (7.2, 42.4) | 0.032 |
| IFNα2a | 71.2 (27.7, 145.4) | 71.4 (29.1, 146.8) | 70.7 (26.7, 139.5) | 0.28 |
| IL-10 | 4.9 (2.41, 9.62) | 4.8 (2.1, 9.4) | 5.2 (2.7, 9.8) | 0.29 |
| MCP-1 | 8848.5 (5114.2, 13533.7) | 8030.3 (4777.1, 12979.8) | 9292 (5191.9, 13632.2) | 0.31 |
| IL-2 | 13.6 (6.7, 25.6) | 13.2 (6.2, 25.7) | 13.9 (7.5, 25.3) | 0.35 |
| IP-10 | 902.2 (292.8, 2229.6) | 907.6 (264.9, 2252.5) | 887.8 (323.4, 2205.8) | 0.41 |
Outcomes and p-values significant for sex are indicated in bold. The p-value for neutralizing antibody was calculated using the Wilcoxon non-parametric test; cytokine/chemokine p-values are from coefficients of univariate regression.