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. 2021 Sep 20;24(1):157–166. doi: 10.1007/s11307-021-01646-5

Table 2.

Averaged standardized uptake value ratios to cerebellum (SUVRCB) from different brain regions of transgenic APP/PS1-21 (TG) and wild-type (WT) mice at different periods after [18F]F-DPA, [18F]DPA-714, and [11C]PBR28 injection

[18F]F-DPA [18F]DPA-714 [11C]PBR28
TG WT TG/WT ratio TG WT

TG/WT

ratio

 TG WT

TG/WT

ratio
10–20 min Brain 1.05 ± 0.03 0.84 ± 0.03 1.25 0.95 ± 0.02 0.92 ± 0.05 1.03 *** 0.97 ± 0.03 0.90 ± 0.03 1.08 ***
Cortex 1.02 ± 0.05 0.70 ± 0.02 1.46 0.83 ± 0.03 0.79 ± 0.04 1.05 *** 0.86 ± 0.04 0.77 ± 0.03 1.12 ***
Hippocampus 1.10 ± 0.06 0.74 ± 0.04 1.49 0.96 ± 0.04 0.92 ± 0.07 1.04 *** # 1.01 ± 0.04 0.89 ± 0.06 1.13 ***
Striatum 1.04 ± 0.05 0.67 ± 0.04 1.55 0.89 ± 0.02 0.82 ± 0.06 1.09 *** 0.96 ± 0.05 0.82 ± 0.04 1.17 ***
Thalamus 0.97 ± 0.05 0.69 ± 0.06 1.41 0.98 ± 0.03 0.92 ± 0.08 1.07 *** # 1.03 ± 0.05 0.90 ± 0.07 1.14 ***
20–40 min Brain 1.06 ± 0.05 0.85 ± 0.04 1.25 0.95 ± 0.02 0.88 ± 0.05 1.08 *** 0.99 ± 0.03 0.87 ± 0.03 1.14 *
Cortex 1.03 ± 0.05 0.71 ± 0.03 1.45 0.86 ± 0.04 0.76 ± 0.04 1.13 * 0.91 ± 0.04 0.74 ± 0.03 1.23
Hippocampus 1.10 ± 0.07 0.73 ± 0.06 1.51 0.97 ± 0.04 0.86 ± 0.07 1.13*** ## 1.05 ± 0.05 0.83 ± 0.05 1.27***
Striatum 1.03 ± 0.06 0.66 ± 0.05 1.56 0.91 ± 0.02 0.76 ± 0.05 1.19 *** 1.00 ± 0.05 0.77 ± 0.04 1.30 ***
Thalamus 0.97 ± 0.05 0.66 ± 0.06 1.47 0.96 ± 0.03 0.82 ± 0.07 1.17 *** # 1.02 ± 0.04 0.81 ± 0.07 1.26 ***
40–60 min Brain 1.07 ± 0.05 0.87 ± 0.04 1.23 0.97 ± 0.02 0.86 ± 0.04 1.12 * 1.02 ± 0.03 0.86 ± 0.03 1.19
Cortex 1.05 ± 0.05 0.74 ± 0.03 1.42 0.88 ± 0.04 0.73 ± 0.04 1.21 0.96 ± 0.04 0.73 ± 0.03 1.31
Hippocampus 1.09 ± 0.07 0.72 ± 0.04 1.51 0.98 ± 0.04 0.81 ± 0.06 1.21 *** ## 1.08 ± 0.04 0.79 ± 0.04 1.37 *
Striatum 1.05 ± 0.07 0.68 ± 0.06 1.54 0.91 ± 0.03 0.71 ± 0.05 1.28 ** 1.04 ± 0.02 0.73 ± 0.04 1.42
Thalamus 0.97 ± 0.05 0.67 ± 0.07 1.45 0.93 ± 0.03 0.74 ± 0.06 1.26 ** 1.03 ± 0.05 0.76 ± 0.06 1.36

Averaged SUVRCB and standard deviations in whole brain, cortex, hippocampus, striatum, and thalamus of transgenic APP/PS1-21 (TG) and wild-type (WT) mice at different periods after injection (10–20, 20–40, and 40–60 min) using [18F]F-DPA, [18F]DPA-714, and [11C]PBR28 (n = 5–6). * denotes significant differences between [18F]F-DPA SUVRCB TG/WT ratios, and [18F]DPA-714, and [11C]PBR28 SUVRCB TG/WT ratios. # denotes significant differences between [18F]DPA-714 and [11C]PBR28 SUVRCB TG/WT ratios. *p < 0.05, ** p < 0.01, *** p < 0.001, #p < 0.05, ##p < 0.01