Table 6.

Cytochrome properties and skin permeation of identified compounds from the aqueous extract of S. torvum unripe fruits

Compound no	Compound name	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor	Log Kp (Skin permeation) (cm/s)
1	Ergost-25-ene-3,6-dione, 5,12-dihydroxy-, (5.alpha.,12.beta.)-	No	No	No	No	No	− 5.18
2	Aspidospermidin-17-Ol, 1-acetyl-16-methoxy-	No	No	No	Yes	No	− 6.42
3	2-[3,4-dichlorophenyl]-4-[[2-[1-methyl-2-pyrrolidinyl]ethyl]amino]-6-[trichloromethyl]-S-triazine	No	Yes	Yes	Yes	Yes	− 5.03
4	Dihydroartemisinin, 10-O-(t-butyloxy)-	Yes	No	No	No	No	− 5.24
5	3-[(2-fluoroanilino)methyl]-5-(2-methoxyphenyl)-1,3,4-oxadiazole-2(3 h)-thione	Yes	Yes	Yes	No	Yes	− 5.44
6	2(1H)-naphthalenone, 5-[2-(3-furanyl)ethyl]octahydro-1,5,6,8a-tetramethyl-,	No	No	No	Yes	No	− 4.33
7	4H-1-benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-3,5-dihydroxy-7-methoxy-	Yes	No	Yes	Yes	Yes	− 6.61
8	2-butenoic acid, 2-methyl-, 4,4a,5,6,7,8,8a,9-octahydro-8a-hydroxy-3,4a,5-trimethylnaphtho[2,3-b]furan-6-yl ester	No	No	No	Yes	No	− 5.51
9	Benzonitrile, 4-(4-ethylcyclohexyl)-, trans-	No	No	Yes	Yes	No	− 4.07
10	1-(2-adamantylidene) semicarbazide	No	No	No	No	No	− 6.85
11	Doxorubicin (synthetic drug)	No	No	No	No	No	− 8.71