Fig. 1.
A suggested protocol for the diagnostic work-up and the treatment of acute ischemic stroke in children. Legend: ED Emergency Department, rTPA recombinant tissue plasminogen activator, PICU pediatric intensive care unit, ANICU adults neurological intensive care unit, NICU neonatal intensive care unit, pedNIHSS Pediatric National Institute of Health Stroke Scale, ECG electrocardiogram, PCR protein C reactive, Inr interventional neuroradiologist, MRI magnetic resonance imaging, DWI diffusion weighted imaging, ADC apparent diffusion coefficient, FLAIR fluid attenuated inversion recovery, TOF time of flight angiography, MRA magnetic resonance angiography, COW circle of Willis, CT computed tomography, ASA acetylsalicylic acid, PT prothrombin time, INR international normalized ratio, aPTT activated partial thromboplastine time, LP lumbar puncture, CNS central nervous system, MCA middle cerebral artery, LMWH low molecular-weight heparin