Table 2.

Main published institutional protocols about the management of pediatric stroke in the last 5 years ^{49, 50, 52, 53, 54, 55}

Article	No. of enrolled patients	Number of patients diagnosticated arterial ischemic stroke	Time of application of protocol	Main symptoms at onset	PedNHISS	Time to neuroimaging	Number of treated patients	% of success of treatment	Number of patients with complications
Rivkin et al. (2019)49	65 pt presenting with brain attack symptoms	6	2.5 years	Focal motor symptoms, sensory deficit, headache	< 4 (65% patients); > 4 (32% patients); not documented in 3 patients	82 min	Not available	Not available	Not available
Tabone et al. (2017)50	13 patients with acute ischemic stroke	13	3.3 years	Focal motor symptoms, language disorder	Median pedNIHSS 10	165 min	15 (11 pt rTPA, 4 pt endovascular procedure)	Not available	No intracranial or peripheral bleeding after treatment. One early death (malignant stroke). mRS score at 3 months 0–2
Ladner et al. (2015)55	124 stroke alerts	21	3 years	Focal motor symptoms, altered mental status, headache	Not available	94 min (to MRI) 59 min (to CT)	11 (1 pt rTPA, 2 pt mechanical thrombectomy)	Not available	Median pediatric stroke outcome measure 0.75 (IQR, 0–2.13), mild-to-moderate ongoing neurological deficits with effect on function
DeLaroche et al. (2016)52	36 stroke alert activations	7	4 years	Neurological deficit, headache, altered mental status, gait abnormalities, seizures	Not available	46 min (to CT) 320 min (to MRI)	Not available	100%	None patient reported complications (64% of pts are discharged home. 36% to in-patients rehabilitation. No deaths)
Shack et al. (2016)53	112	122	7 years	Not available	Median pedNIHSS 7 (4–12)	90 min	Not available	Not available	Not available
Wharton et al. (2020)54	385 stroke alert activation	80 stroke (not specified acute ischemic/haemorrhagic)	7 years	Not available	Median pedNIHSS 7.5–10	79 min	57 (0 pt rTPA, 4 pt endovascular procedure)	Not available	Not available