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. 2021 Aug 9;24(1):115–125. doi: 10.1007/s11307-021-01632-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Structural formulas of the radioligands examined. [⁶⁸Ga]Ga-PSMA-11 and [⁸⁹Zr]Zr-PSMA-DFO contain 3 components: the pharmacophore lysine-urea-glutamate, the chelating agent, and the linker. For [⁶⁸Ga]Ga-PSMA-11, HBED-CC and 6-aminohexanoic (ahx) were used as chelator and linker, respectively. For [⁸⁹Zr]Zr-PSMA-DFO, DFO was used as chelator and naphthylalanine and tranexamic acid (2NaI-AMCHA) were functionalized as linker. In the case of [¹⁸F]F-JK-PSMA-7, the lysine-urea-glutamate scaffold was coupled to tetrafluorophenyl 6-fluoro-4-methoxynicotinate (6-F-4-OMe-Nic-OTfp).