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. 2021 Aug 9;24(1):115–125. doi: 10.1007/s11307-021-01632-x

Table 3.

Biodistribution data (%ID/g) of [89Zr]Zr-PSMA-DFO, [68Ga]Ga-PSMA-11, and [18F]F-JK-PSMA-7 in CB17-SCID mice bearing LNCaP tumor xenografts (n = 5) for each tracer and time point)

[89Zr]Zr-PSMA-DFO [68Ga]Ga-PSMA-11 [18F]F-JK-PSMA-7
2 h 4 h 24 h 2 h 4 h 2 h 4 h
LNCAP-tumor 26.3 ± 5.3 22.8 ± 1.5 14.9 ± 1.2 19.4 ± 2.4 23.2 ± 10.6 20.2 ± 2.4 21.3 ± 1.5
Liver 0.95 ± 0.15 0.79 ± 0.17 0.37 ± 0.03 3.17 ± 0.18** 0.65 ± 0.21 4.44 ± .0.78* 3.75 ± 0.50**
Spleen 0.49 ± 0.07 0.61 ± 0.09 0.36 ± 0.08 40.9 ± 9.3**§ 62.5 ± 21.5**§ 2.15 ± 0.45* 1.57 ± 0.22*
Kidneys 86.7 ± 18.7§ 41.3 ± 2.37§ 15.4 ± 4.1 231 ± 41*§ 226 ± 25§ 27.2 ± 2.6 26.0 ± 3.5*
Blood 0.14 ± 0.02 0.13 ± 0.04 0.05 ± 0.01 1.34 ± 0.20 0.21 ± 0.03 0.15 ± 0.04 0.12 ± 0.03
Muscle 0.05 ± 0.02 0.08 ± 0.02 0.03 ± 0.01 0.54 ± 0.15 0.42 ± 0.11 0.07 ± 0.02 0.19 ± 0.03
Bone 0.15 ± 0.04 0.13 ± 0.03 0.18 ± 0.02 1.19 ± 0.31 0.50 ± 0.19 0.18 ± 0.03 0.20 ± 0.03
Thyroid 0.18 ± 0.03 0.13 ± 0.02 0.05 ± 0.01 2.13 ± 0.27* 4.44 ± 2.9 0.19 ± 0.02 0.20 ± 0.02
Lung 0.5 ± 0.04 0.12 ± 0.03 0.04 ± 0.01 3.27 ± 1.03 1.23 ± 0.13* 0.18 ± 0.01 0.18 ± 0.04
Intestine 0.65 ± 0.15 0.54 ± 0.10 0.25 ± 0.08 1.50 ± 0.59 0.65 ± 0.30 0.89 ± 0.18 1.53 ± 0.31
Heart 0.11 ± 0.05 0.12 ± 0.03 0.09 ± 0.02 1.10 ± 0.36 1.35 ± 0.70 0.12 ± 0.02 0.10 ± 0.02
Prostate 0.15 ± 0.04 1.12 ± 0.16 0.50 ± 0.01 4.09 ± 1.15 1.67 ± 0.37 0.22 ± 0.03 0.60 ± 0.16
Tumor/blood 183 ± 42# 180 ± 61# 309 ± 89 15 ± 3*§ 112 ± 57*§ 142 ± 24§ 175 ± 30§
Tumor/kidneys 0.31 ± 0.06§ 0.55 ± 0.01§ 1.02 ± 0.28 0.09 ± 0.02**§ 0.10 ± 0.05**§ 0.74 ± 0.08** 0.83 ± 0.13**
Tumor/muscle 534 ± 62 297 ± 62§ 450 ± 38 37 ± 8**§ 58 ± 36**§ 282 ± 71**§ 114 ± 14**§
Tumor/liver 27.5 ± 3.2§ 29.6 ± 5.1§ 40.0 ± 1.1 6.2 ± 1.0**§ 34.6 ± 6.6 4.7 ± 1.2**§ 5.7 ± 0.7**§

*p < 0.05, **p < 0.01; significantly different from [89Zr]Zr-PSMA-DFO uptake at the corresponding time point (three-way ANOVA followed by Tukey’s multiple comparisons test for organs, two-way ANOVA for ratios)

#p < 0.05, §p < 0.01; significantly different from [89Zr]Zr-PSMA-DFO uptake at 24 h (two-way ANOVA, mixed-effects model, followed by Tukey’s multiple comparisons test for organs, one-way ANOVA for ratios)