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H&E-stained colon sections. (A) Section from a mock-infected (sterile broth) mouse showing normal colonic crypt architecture. (B) Section from an MPEC-infected mouse showing crypt hyperplasia, goblet cell depletion, and mild inflammation. (C) DBS100-induced necrosis showing epithelial damage, severe mucosal inflammation with an accompanying inflammatory exudate, and submucosal edema. All panels are at an identical level of magnification.
