Table 2.
Adverse events related or possibly related to the intervention
| Treatment-emergent adverse events | Daily caloric restriction (n = 15) | Intermittent fasting (n = 13) |
|---|---|---|
| Hunger | 5 (33%) | 11 (85%) ∗ |
| Gastrointestinal distress (abdominal discomfort, constipation, nausea, or diarrhea) | 4 (27%) | 8 (62%) |
| Fatigue | 1 (7%) | 8 (62%) ∗ |
| Lightheadedness/dizziness | 3 (20%) | 5 (39%) |
| Cold intolerance | 1 (7%) | 7 (54%) ∗ |
| Change in mood | 2 (14%) | 4 (31%) |
| Irritability | 1 (7%) | 6 (46%) ∗ |
| Insomnia | 2 (13%) | 7 (54%) ∗ |
| Headache | 2 (13%) | 4 (31%) |
| Impaired concentration and/or cognitive difficulties | 0 (0%) | 3 (23%) |
| Tremor | 0 (0%) | 1 (8%) |
Data are n (%). ∗p < 0.05 vs. daily caloric restriction by Fisher’s exact test.