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Selectivity of furanylbenzamide inhibitors for SHP2 over related phosphatases PTP1B and STEP (IC50 values in micromolar; each PTP construct was comprised of the catalytic domain)
| PTP | SBI-2130 | SBI-4668 | SBI-3192 | SBI-3404 | SBI-3405 |
|---|---|---|---|---|---|
| SHP2 | 0.22 | 0.73 | 1.1 | 1.4 | 2.0 |
| PTP1B | 6.8 | 9.4 | 1.9 | 7.4 | 5.3 |
| STEP | 44 | 53 | 27 | >100 | 7.7 |
