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. 2021 Dec 23;298(1):101532. doi: 10.1016/j.jbc.2021.101532

Figure 8.

Figure 8

Pharmacological inhibition of IRE1α RNase alleviates hepatic I/R injury. Male C57BL6 mice were intraperitoneally injected daily with DMSO (veh) or 4μ8C (10 mg/kg body weight) for 3 days prior to hepatic I/R injury (n = 3 mice per group). A, representative images of hematoxylin and eosin staining of liver sections with the necrotic regions indicated. The area of necrosis per field was quantified. Scale bar, 100 μm. B, serum ALT and AST levels. C, representative images of TUNEL staining of liver sections. TUNEL-positive cells per field were quantified. Scale bar, 15 μm. All data represent the mean ± SD. ∗p < 0.05 and ∗∗∗p < 0.001 by one-way ANOVA.