Table 3.
Laboratory data of mice
| Indicators | Normal C57BL/6N mice | Flox mice | CKO heterozygous mice | CKO homozygous mice | p |
|---|---|---|---|---|---|
| WBC (× 109/L) | 9.260 ± 2.581 | 7.827 ± 2.025 | 3.667 ± 1.347 | 3.127 ± 1.637 | < 0.0001* |
| RBC (× 1012/L) | 9.679 ± 0.638 | 9.309 ± 0.790 | 7.923 ± 0.902 | 7.912 ± 0.765 | < 0.0001* |
| Hb (g/L) | 152.7 ± 11.07 | 140.6 ± 10.54 | 126.1 ± 16.64 | 120.6 ± 17.22 | < 0.0001* |
| PLT(× 109/L) | 1249 ± 130.3 | 1213 ± 110.2 | 1106 ± 290.1 | 987.6 ± 126.9 | 0.0008* |
| LDH (U/L) | 439.8 ± 45.11 | 453.1 ± 33.08 | 586.4 ± 51.83 | 832.9 ± 208.9 | 0.0001* |
| TBIL (μmmol/L) | 1.868 ± 0.646 | 1.834 ± 0.475 | 3.064 ± 0.480 | 3.830 ± 0.493 | < 0.0001* |
| IBIL(μmmol/L) | 2.006 ± 0.308 | 1.974 ± 0.385 | 2.294 ± 0.539 | 3.318 ± 0.293 | 0.0032* |
| FHb (mg/L) | 168.1 ± 61.00 | 179.8 ± 62.15 | 333.6 ± 137.7 | 354.1 ± 91.03 | 0.0052* |
| C3a (ng/mL) | 37.05 ± 5.077 | 39.56 ± 9.813 | 46.21 ± 6.659 | 46.00 ± 7.639 | 0.1703 |
| C5a (ng/mL) | 83.80 ± 13.45 | 98.82 ± 38.01 | 124.2 ± 19.53 | 116.3 ± 28.45 | 0.1138 |
| C5b-9 (ng/L) | 174.3 ± 10.79 | 193.0 ± 7.10 | 204.1 ± 6.74 | 217.2 ± 26.39 | 0.0027* |
*There was statistical difference between the four groups (p < 0.05)