Table 2.

Differences in KEGG metabolic pathways between Helicobacter pylori-positive and -negative groups

Class	KEGG pathway		Median ko-abundance
	(ko number)	Pathway	H. pylori	H. pylori
			negative (n = 34)	positive (n = 13)	Pb
M	ko00072†	Synthesis and degradation of ketone bodies	1335885.8	1823878.4	<0.05
M	ko00380†	Tryptophan metabolism	2254680.9	2759405.6	<0.05
M	ko00510	N-glycan biosynthesis	907554.4	700748.0	<0.05
M	ko00565a	Ether lipid metabolism	150966.1	394815.2	<0.001
M	ko00571	Lipoarabinomannan (LAM) biosynthesis	397200.0	191311.5	<0.05
M	ko00591a	Linoleic acid metabolism	85148.3	389478.0	<0.001
M	ko00592a	alpha-Linolenic acid metabolism	132544.9	405656.4	<0.001
M	ko00780a	Biotin metabolism	15103400	19564468	<0.05
M	ko00906a	Carotenoid biosynthesis	129310.3	510048.5	<0.01
M	ko00940†	Phenylpropanoid biosynthesis	348411.2	598460.1	<0.01
M	ko01053	Biosynthesis of siderophore group nonribosomal peptides	2025414.2	1127312.8	<0.01
M	ko01062a	Biosynthesis of terpenoids and steroids	92469.4	428251.7	<0.01

Twelve metabolic pathways that significantly differed among 327 detected pathways. M, metabolism. ^aMost abundant pathways in H. pylori-positive group. ^bCalculated using Mann–Whitney U tests