Figure 1.

R273C is the single dominant TP53 hotspot mutation in IDHmut but not IDHwt astrocytomas. (A) TP53 mutational profiles of IDHmut (left column) and IDHwt (right column) astrocytomas reveal a dominant hotspot at codon 273 which is specific to the IDHmut tumor subset. Note that y-axes are scaled per-plot to clearly show the distributions. (B) Mutations at TP53 codon 273 in IDHmut astrocytomas are dominated by the R273C amino acid change, which occurs at a far higher frequency than other pan-cancer hotspot mutations, including R273H. (C) In contrast, IDHwt astrocytomas are not enriched for this mutation.