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. 2021 Dec 11;4(1):vdab182. doi: 10.1093/noajnl/vdab182

Figure 2.

Figure 2.

Enrichment of TP53 R273C is not accounted for by known mutational mechanism signatures. (A–B) DNA context of select point mutations at hotspot codons in TP53 (A) and IDH1 (B). (C) Consequences of C>T transitions at methylated CpG site at these codons, grouped by trinucleotide context. At right, the frequency at which each trinucleotide is found within the four COSMIC SBS mutational signatures that are enriched for the G(C>T)G or A(C>T)G transitions (corresponding to TP53R273C and IDH1R132H respectively). (D) The profile of TP53 mutations in IDH-mutant astrocytomas does not match these SBS signatures (UPMC cohort). To avoid confounding effects, mutations at the dominant hotspot codon 273 are excluded.