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. 2021 Dec 11;4(1):vdab182. doi: 10.1093/noajnl/vdab182

Figure 4.

Figure 4.

Comutation analysis of TP53 R273C mutants and tumors with other TP53 mutations. (A–B) The genomic landscape of IDHmut astrocytomas, grouped by sex and TP53R273C status, for WHO grades 2-3 (A) and WHO grade 4 (B) tumors. (C) Fewer female tumors with TP53R273C have additional genomic alterations than those with other TP53 mutations; this pattern is reversed in male tumors (P < .05, chi-squared test). (D) TP53R273C mutant WHO grade 4 tumors show lower incidence of CDKN2A copy number loss than those with other TP53 mutations (P < .01, chi-squared test); RB1 loss is more common (see (B)).