Figure 2.

Generation of the V3 (median‐sized) phantom used for IC validation. In each case, the coronal view is shown in left and sagittal view in right. A heterogenous phantom with volume glandular fraction corresponding to 50% of pollution used in modeling is shown in (a). The corresponding physical V3 phantom (b) is scanned twice. The reconstructed images are subtracted and normalized to form realistic quantum noise distribution (c). The physical phantom is also cupping corrected to simulate a “ground truth” background model (d). The background and noise images are added to the original heterogenous image to generate the V3 mathematical phantom (e).