Table 1.
Patient demographics and IgG anti-S results.
| Cohort HCW vaccination | Comparator groups | ||||
|---|---|---|---|---|---|
| COVID-19 Naive | Prior COVID-19a | Hosp. 6 weeks | Hosp. 3 months | HCW 3 months | |
| Number of individuals | 126 | 24 | 64 | 42 | 112 |
| Median age (years [range]) | 49.5 (39.3-60) | 54 (40.3-57.5) | 62.5 (56.8-68) | 65 (54.5-72.8) | 47.6 (35.0-55.5) |
| Male/Female (% men) | 35/91 (28%) | 2/22 (8%) | 39/25 (61%) | 25/17 (60%) | 14/98 (13%) |
| Severity (%) | |||||
| Asymptomatic | NA | 9 (38%) | NA | NA | 8 (7%) |
| Mild | NA | 11 (46%) | NA | NA | 98 (88%) |
| Moderate | NA | 4 (17%) | 28 (44%) | 15 (28%) | 6 (5%) |
| Severe/critical | NA | 0 (0%) | 36 (56%) | 38 (72%) | 0 (0%) |
| Median IgG anti-S level (AU/mL) (P25-P75) | |||||
| Baseline | 2.4 (1.1-4.8) | 287 (104-629)c | NA | NA | NA |
| 3 weeks | 559 (244-1133) | 24444 (15697-33073) c | NA | NA | NA |
| 6 weeks | 9887 (5599-16189) | 32538 (24061-42078) c | 5941 (2369-10470)d | NA | NA |
| 3 months | 2942 (1642-5016)b | 15633 (9355-21382) ,b,c | NA | 3542 (606-5859) d | 624 (296-1149)e |
| High probability neutralizing antibodies (≥4160 AU/mL) (%) | |||||
| Baseline | 0 (0%) | 0 (0%) | NA | NA | NA |
| 3 weeks | 1 (1%) | 23 (96%)c | NA | NA | NA |
| 6 weeks | 108 (86%) | 24 (100%) | 46 (72%)d | NA | NA |
| 3 months | 37 (32%)b | 20 (91%)b,c | NA | 23 (55%)e | 4 (4%)e |
HCW = health care workers; Hosp. = hospitalized COVID-19 patients; NA = not applicable; AU = arbitrairy units.
a
Median time between positive PCR and administration of the first dose was 274 days (range:39-301).
b
Eleven participants were not tested at 3 months (9 COVID-19 naive and 2 prior COVID-19).
c
P < 0.01 prior COVID-19 vs COVID-19 naïve.
d
P < 0.01 vs prior COVID-19, but not vs COVID-19 naive at 6 weeks.
e
P < 0.01 vs all at 3 months.