Fig. 4.

RBD mutation regions of the LMM52630 subject in contact with neutralizing antibodies. (A) The comparison of the mutated sequences with the wild type. Below, the structural model with the selected residues, depicted (red color) for wild and mutated RBD region. The model of the monomer was obtained from the 7CWL PDB structure. (B) The contact region among the RBD (pink), the Fab CR3022 neutralizing antibody (light and heavy chains, represented in blue and green colors, respectively) and the residues C379 and Y380 (red). (C) The same RBD region contacting the neutralizing antibody EY6A (the light chain in purple and heavy in grey). RBD = Receptor binding domain; WT = Wild type. (Color version of figure is available online.)