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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Nature. 2021 Jul 12;596(7872):410–416. doi: 10.1038/s41586-021-03791-x

Fig. 1 |. BNT162b2 vaccination induces robust antibody and T cell responses.

Fig. 1 |

a, b, Serum anti-S IgG titres (a) (half-maximal effective concentration (EC50)) and live-virus neutralizing antibody titres (b) (half-maximal inhibitory concentration (IC50)), measured by enzyme-linked immunosorbent assay and focus reduction neutralization titre assays, respectively. c, Live-virus neutralizing antibody response against the wild-type (WA1) or B.1.351 variant measured in day-42 sera. d, e, Spike-specific CD4 (d) and CD8 (f) T cell IFNγ response in blood. Each dot represents a participant (n = 56 (a, b), 30 (c) and 38 (d, e)). Statistical differences were calculated using two-sided Wilcoxon matched-pairs signed-rank test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Boxes show median and 25th–75th percentiles, and whiskers show the range.