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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Nature. 2021 Jul 12;596(7872):410–416. doi: 10.1038/s41586-021-03791-x

Extended Data Table 2 |.

Vaccine side effects and symptoms

Variable N (%) Variable N (%) p-value

First Dose Second Dose
 None 11 (19.6)  None 5 (8.9) 0.177
 Fever 2 (3.6)  Fever 7 (12.5) 0.154
 Site tenderness 39 (69.6)  Site Tenderness 40 (71.4) 0.881
 Site swelling 6 (10.7)  Site Swelling 16 (28.6) 0.029
 Site redness 4 (7.1)  Site Redness 14 (25) 0.018
 Muscle aches 15 (26.8)  Muscle aches 29 (51.8) 0.015
 Fatigue 15 (26.8)  Fatigue 21 (37.5) 0.28
 Headache 10 (17.9)  Headache 17 (30.4) 0.167
 Chills 2 (3.6)  Chills 10 (17.9) 0.03
 Joint pain 1 (1.8)  Joint Pain 4 (7.1) 0.349
 Nausea 1 (1.8)  Nausea 2 (3.6) 0.49
 Difficulty breathing 1 (1.8)  Difficulty Breathing 1 (1.8) 1
 Hives 0 (0)  Hives 1 (1.8) 0.993
 Swelling 0 (0)  Swelling 2 (3.6) 0.468
 Tachycardia 0 (0)  Tachycardia 1 (1.8) 0.993
 Rash 0 (0)  Rash 2 (3.6) 0.468
 Dizziness 2 (3.6)  Dizziness 5 (8.9) 0.317
 Sweating 2 (3.6)  Sweating 1 (1.8) 1
 Brain fog 1 (1.8)  Brain Fog 0 (0) 0.993
 Loss of appetite 1 (1.8)  Loss of appetite 0 (0) 0.993
 Rhinitis 1 (1.8)  Rhinitis 0 (0) 0.993
 Paresthesia 1 (1.8)  Paresthesia 1 (1.8) 1
 Diarrhea 1 (1.8)  Diarrhea 0 (0) 0.993
 Vertigo 0 (0)  Vertigo 1 (1.8) 0.993
Site of injection Site of injection
 Right arm 5 (8.9)  Right arm 8 (14.3)
 Left arm 51 (91.1)  Left arm 48 (85.7)

The statistical differences were determined using χ2 test for categorical variables and two-sided t-test for continuous variables considering each parameter individually (no multiple corrections).