Table 2.
List of selected molecular functions and biological processes significantly enriched by flow exposure68
| Cellular function or process | Enrichment score | Enrichment p-value |
|---|---|---|
| Regulation of cell cycle process | 14.8 | 7.0E−29 |
| Cellular response to chemical stimulus | 10.8 | 2.0E−05 |
| Cellular response to growth factor stimulus | 8.7 | 1.7E−04 |
| Regulation of cell proliferation | 7.6 | 5.1E−04 |
| Positive regulation of metaphase/anaphase transition of cell cycle | 7.2 | 7.8E−04 |
| Cell differentiation involved in embryonic placenta development | 7.0 | 6.1E−06 |
| Cellular response to TGF-β stimulus | 6.6 | 1.3E−03 |
| Regulation of cell motility | 5.9 | 5.2E−02 |
| RNA splicing, via transesterification reactions | 5.7 | 6.9E−09 |
| Regulation of cell adhesion | 5.4 | 4.4E−03 |
| Positive regulation of stem cell differentiation | 5.2 | 4.9E−09 |
| Regulation of epithelial to mesenchymal transition | 5.0 | 6.8E−03 |
| Cyclin-dependent protein kinase holoenzyme complex | 5.0 | 1.0E−04 |
Functions and processes with relative enrichment scores greater than 5 and p-values less than 0.01 were considered significant. Descriptions of molecular functions and biological processes were obtained from the Gene Ontology database of the Biometric Research Branch—ArrayTools software package (v4.5.0)22