Fig. 5.

Integration scheme and diagnostic performance of CDKN1A/JUN in predicting ischemic stroke. a A 4 set venn diagram shows the integration strategy among ceRNA, SVM, LASSO regression, and gene pair. The purple pink circle represents for DEFRGs of ceRNA network, the yellow circle represents for DEFRGs screened by SVM, the peach pink circle represents for DEFRGs screened by LASSO regression, the green circle represents for meaningful DEFRGPs in both GSE140275 and GSE22255. As shown, CDKN1A/JUN is the key gene pair. b-d Comparison of ROC analysis between gene pair and single gene in the discovery cohort. b ROCs for CDKN1A. c ROCs for JUN. d ROCs for CDKN1A/JUN gene pair. e-g Comparison of ROC analysis between gene pair and single gene in the validation cohort. e ROCs for CDKN1A. f ROCs for JUN. g ROCs for CDKN1A/JUN gene pair