Table 2.
Distributions of clinicopathological characteristics in two groups
| Variables | LM (−) | LM (+) | P value |
|---|---|---|---|
| N = 16,023 | N = 762 | ||
| Age at diagnosis, n (%) | < 0.001 | ||
| 0–9 | 14 (0.1) | 0 (0.0) | |
| 10–19 | 158 (1.0) | 1 (0.1) | |
| 20–29 | 324 (2.0) | 8 (1.0) | |
| 30–39 | 447 (2.8) | 22 (2.9) | |
| 40–49 | 1238 (7.7) | 97 (12.7) | |
| 50–59 | 4372 (27.3) | 205 (26.9) | |
| 60–69 | 4363 (27.2) | 197 (25.9) | |
| 70–79 | 3185 (19.9) | 144 (18.9) | |
| 80–89 | 1679 (10.5) | 78 (10.2) | |
| 90–99 | 243 (1.5) | 10 (1.3) | |
| Gender, n (%) | |||
| Female | 7784 (48.6) | 324 (42.5) | 0.001 |
| Male | 8239 (51.4) | 438 (57.5) | |
| Race, n (%) | 0.215 | ||
| White | 12,213 (76.2) | 565 (74.1) | |
| Black | 2100 (13.1) | 120 (15.7) | |
| Asian or Pacific Islander | 1601 (10.0) | 72 (9.4) | |
| American Indian/Alaska Native | 109 (0.7) | 5 (0.7) | |
| Marital status at diagnosis, n (%) | < 0.001 | ||
| Married | 8918 (55.7) | 376 (49.3) | |
| Single | 2611 (16.3) | 167 (21.9) | |
| Widowed | 1740 (10.9) | 90 (11.8) | |
| Divorced | 1417 (8.8) | 83 (10.9) | |
| Unknown | 1131 (7.1) | 36 (4.7) | |
| Separated | 166 (1.0) | 10 (1.3) | |
| Unmarried or Domestic Partner | 40 (0.2) | 0 (0.0) | |
| Primary site, n (%) | < 0.001 | ||
| Rectum, NOS | 4502 (28.1) | 239 (31.4) | |
| Sigmoid colon | 3540 (22.1) | 162 (21.3) | |
| Ascending colon | 1969 (12.3) | 90 (11.8) | |
| Cecum | 1884 (11.8) | 95 (12.5) | |
| Appendix | 1081 (6.7) | 3 (0.4) | |
| Rectosigmoid junction | 967 (6.0) | 94 (12.3) | |
| Transverse colon | 863 (5.4) | 26 (3.4) | |
| Descending colon | 569 (3.6) | 18 (2.4) | |
| Hepatic flexure of colon | 356 (2.2) | 17 (2.2) | |
| Splenic flexure of colon | 194 (1.2) | 9 (1.2) | |
| Colon, NOS | 53 (0.3) | 6 (0.8) | |
| Overlapping lesion of colon | 45 (0.3) | 3 (0.4) | |
| Tumor size, mm, mean (SD) | 17.5 (22.5) | 52.1 (39.2) | < 0.001 |
| Tumor grade, n (%) | < 0.001 | ||
| Well differentiated; Grade I | 5131 (32.0) | 55 (7.2) | |
| Moderately differentiated; Grade II | 9853 (61.5) | 567 (74.4) | |
| Poorly differentiated; Grade III | 891 (5.6) | 127 (16.7) | |
| Undifferentiated; anaplastic; Grade IV | 148 (0.9) | 13 (1.7) | |
| Tumor type, n (%) | < 0.001 | ||
| Adenocarcinoma, NOS | 4859 (30.3) | 608 (79.8) | |
| Adenocarcinoma in tubulovillous adenoma | 3669 (22.9) | 43 (5.6) | |
| Adenocarcinoma in adenomatous polyp | 3495 (21.8) | 40 (5.2) | |
| Carcinoid tumor, NOS | 2287 (14.3) | 4 (0.5) | |
| Adenocarcinoma in villous adenoma | 596 (3.7) | 13 (1.7) | |
| Neuroendocrine carcinoma, NOS | 495 (3.1) | 7 (0.9) | |
| Mucinous adenocarcinoma | 281 (1.8) | 18 (2.4) | |
| Squamous cell carcinoma, NOS | 59 (0.4) | 1 (0.1) | |
| Atypical carcinoid tumor | 49 (0.3) | 0 (0.0) | |
| Signet ring cell carcinoma | 32 (0.2) | 2 (0.3) | |
| Mucin-producing adenocarcinoma | 30 (0.2) | 2 (0.3) | |
| Tubular adenocarcinoma | 30 (0.2) | 0 (0.0) | |
| Gastrointestinal stromal sarcoma | 17 (0.1) | 0 (0.0) | |
| Villous adenocarcinoma | 12 (0.1) | 0 (0.0) | |
| Carcinoma, NOS | 11 (0.1) | 8 (1.0) | |
| Other | 101 (0.6) | 16 (2.1) | |
| N, n (%) | < 0.001 | ||
| N0 | 14,711 (91.8) | 462 (60.6) | |
| N1 | 1179 (7.4) | 267 (35.0) | |
| N2 | 133 (0.8) | 33 (4.3) | |
| CEA, n (%) | < 0.001 | ||
| Positive | 999 (6.2) | 524 (68.8) | |
| Negative | 4899 (30.6) | 68 (8.9) | |
| Borderline | 28 (0.2) | 3 (0.4) | |
| Unknown | 10,097 (63.0) | 167 (21.9) | |
| Tumor deposits, n (%) | < 0.001 | ||
| No tumor deposits | 10,867 (67.8) | 123 (16.1) | |
| Tumor Deposits identified | 111 (0.7) | 11 (1.4) | |
| Unknown | 5045 (31.5) | 628 (82.4) | |
| Perineural invasion, n (%) | < 0.001 | ||
| No | 11,040 (68.9) | 310 (40.7) | |
| Yes | 143 (0.9) | 10 (1.3) | |
| Unknown | 4840 (30.2) | 442 (58.0) |
LM liver metastasis, NOS not otherwise specified, SD standard deviation, CEA carcinoembryonic antigen