Table 4.
Multiplicative and additive interactions between CSI and demographic and lifestyle characteristics
| Stratified factors | Discovery stage: TNCHS study a | Replication stage: CHNS study b | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MetS ( +)/All | CSI categories | Ptrendc | Pinteraction d | RERI (95%Cl) e |
MetS ( +)/All | CSI categories | P trend c | P interaction d | RERI (95%Cl) e |
|||||
| Tertile 1 | Tertile 2 | Tertile 3 | Tertile 1 | Tertile 2 | Tertile 3 | |||||||||
| OR (95%Cl) | OR (95%Cl) | OR (95%Cl) | OR (95%Cl) | OR (95%Cl) | OR (95%Cl) | |||||||||
| Sex | 0.245 |
0.31 (− 0.19 to 0.81) |
0.312 |
− 0.07 (− 0.69 to 0.54) |
||||||||||
| Female | 1932/8149 | 1.19 (0.73–1.96) | 1.78 (0.98–3.23) | 1.33 (0.67–2.66) | 0.050 | 755/4589 | 1.03 (0.53–2.01) | 1.42 (0.67–3.03) | 0.93 (0.45–1.93) | 0.738 | ||||
| Male | 1614/7073 | 1.22 (0.95–1.56) | 1.82 (1.46–2.28) | 2.15 (1.72–2.69) | < 0.001 | 804/3976 | 1.05 (0.80–1.36) | 1.26 (1.00–1.60) | 1.17 (0.91–1.50) | 0.085 | ||||
| Age | 0.015 |
− 0.35 (− 0.86 to 0.16) |
0.001 |
− 1.29 (− 2.13 to − 0.45) |
||||||||||
| < 70 years | 1988/9544 | 1.25 (0.96–1.63) | 1.87 (1.47–2.37) | 2.31 (1.81–2.95) | < 0.001 | 1313/7591 | 0.97 (0.76–1.24) | 1.38 (1.09–1.76) | 1.33 (1.03–1.71) | 0.004 | ||||
| ≥ 70 years | 1558/5678 | 1.04 (0.71–1.52) | 1.46 (0.99–2.15) | 1.41 (0.95–2.08) | 0.020 | 246/974 | 0.71 (0.29–1.75) | 0.61 (0.27–1.37) | 1.07 (0.62–1.84) | 0.813 | ||||
| Exercise status | 0.542 |
− 0.10 (− 0.29 to 0.49) |
0.930 |
0.004 (− 0.32 to 0.31) |
||||||||||
| Exercise/like | 2334/9267 | 1.04 (0.80–1.35) | 1.81 (1.42–2.30) | 1.97 (1.54–2.53) | < 0.001 | 462/2608 | 1.06 (0.72–1.57) | 1.28 (0.87–1.90) | 0.73 (0.47–1.15) | 0.701 | ||||
| No exercise /dislike | 1212/5955 | 1.68 (1.13–2.50) | 1.66 (1.12–2.47) | 2.08 (1.43–3.01) | < 0.001 | 1097/5957 | 1.44 (1.06–1.95) | 1.31 (0.99–1.73) | 1.11 (0.84–1.45) | 0.180 | ||||
| Alcohol consumption | 0.054 |
− 0.38 (− 0.83 to 0.07) |
0.597 |
0.16 (− 0.15 to 0.46) |
||||||||||
| Never consumed alcohol | 3204/14,057 | 1.23 (0.92–1.65) | 1.89 (1.43–2.50) | 2.48 (1.86–3.30) | < 0.001 | 1038/5799 | 1.15 (0.78–1.69) | 1.35 (0.95–1.91) | 0.88 (0.62–1.24) | 0.839 | ||||
| Past/current consumer | 342/1165 | 1.02 (0.69–1.52) | 1.37 (0.94–1.99) | 1.44 (1.00–2.08) | 0.038 | 521/2766 | 1.23 (0.89–1.70) | 1.36 (1.00–1.86) | 1.31 (0.94–1.82) | 0.047 | ||||
CSI comprehensive smoking index, OR: odds ratio, CI confidence interval, BMI body mass index, RERI relative excess risk due to interaction
aAdjusted for age, physical activity, BMI, dietary habits
bAdjusted for sex, age, BMI, province, region
cLinear trend tests were performed by entering the median value of each group of cigarette smoking variables as continuous variables in the models
dP values for the multiplicative interactions between CSI and stratified factors
eIn the calculation of RERI, smoking status was modeled as a dichotomous variable (never vs. ever)