Table 5.

Factors affecting the adherence and persistence to GLP-1RA

Reasons for treatment discontinuation	Factors for higher adherence and persistence
Inadequate blood glucose control [67]	Initiating treatment with low dose [67, 75]
Gastrointestinal side effects (including nausea/vomiting) [67, 75, 77]	Ease of use of injection device [75, 77]
Preference for oral medication over injection [95]	Weekly dosing rather than daily or twice daily dosing [72]
High cost [95]	Early (within 6 months) weight loss [73]
Injection site reaction [95]	Early (within 6 months) HbA1c level reduction [73]
Inadequate body weight reduction [73]
Inconvenience of injection schedule [67, 71]
Injection-related concerns (including pain and fear) [76]