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. Author manuscript; available in PMC: 2022 Sep 29.
Published in final edited form as: ACS Appl Mater Interfaces. 2021 Sep 20;13(38):45300–45314. doi: 10.1021/acsami.1c14082

Figure 2. Screening and identification of NAMPs responsible for inflammasome activation by measuring IL-1β release.

Figure 2.

(A) Structures of different polymer constructs used to synthesize sNPs for testing varied NAMPs. Four different NAMPs tested were: Surface charge, Core rigidity, Surface hydrophobicity, and Core hydrophobicity. (B) Concentration-dependent quantification of IL-1β release by LPS-primed iBMDMs treated with a series of supramolecular nanoparticles (sNPs) containing different NAMPs as listed before. Data shown are mean ± S.E.M. (n=6). Statistical significance was determined using Ordinary one-way ANOVA and Dunnett’s multiple comparisons test. *p < 0.05, **p<0.01, ***p<0.001, ****p<0.0001.