Skip to main content
. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Neurotoxicology. 2021 Sep 17;87:94–105. doi: 10.1016/j.neuro.2021.09.002

Figure 5.

Figure 5.

Behavior for mice from Study 2, at 50 weeks (experimental timeline shown in Figure 4A). (A) Fold change in rotarod performance from 11 to 50 weeks of age. On average, all groups performed worse on the task at 50 weeks compared to 11 weeks. YAC128 mice performance declined to a greater extent than WT. (B) Time spent in open zone of the EZM at 50 weeks. The three WT groups that received any Mn exposure combined were significantly different from vehicle treated WT mice by t-test. (C) Total distance travelled during 30 minutes in the open field. YAC128 mice travelled less than WT, with no effects of any length Mn exposure in either genotype. For all, mean ± S.E.M. plotted unless otherwise noted. Asterisks * indicate genotype effect, pound # indicates Mn effect within genotype. #/* p <0.05, **, p<0.01, *** p<0.001, **** p<0.0001. n=12-15 per genotype-treatment group with approximately equal number of males and females.