Table 2: Enrichment of apoptotic pathways is cluster and MeHg-exposure paradigm-specific.
Enrichment of apoptotic pathways in day 38 developing cortical cultures were extracted form our Go analysis (suppl. Tables 5–8) for each cell type (cluster) and at each MeHg treatment paradigm (E at 0.1 μM, E at 1 μM, E+L at 0.1 μM and E+L at 1 μM). The enrichment factor (EF) is listed for each pathway.
| MeHg exposure: E at 0.1 μM | ||
| Cluster | pathway | EF |
| 0 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 3.44 |
| 0 | regulation of intrinsic apoptotic signaling pathway | 2.28 |
| 1 | release of cytochrome c from mitochondria apoptotic process | 1.73 |
| 1 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 4.15 |
| 1 | regulation of apoptotic process | 1.38 |
| 5 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | 14.14 |
| 2 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 4.44 |
| 3 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | 14.21 |
| MeHg exposure: E at 1.0 μM | ||
| Cluster | pathway | EF |
| 0 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 4.02 |
| 0 | positive regulation of apoptotic process | 1.73 |
| 0 | apoptotic process | 1.51 |
| 0 | negative regulation of apoptotic process | 1.49 |
| 1 | negative regulation of apoptotic signaling pathway | 2.59 |
| 1 | positive regulation of apoptotic process | 1.95 |
| 1 | apoptotic process | 1.58 |
| 2 | mitochondrial outer membrane permeabilization positive regulation of mitochondrial membrane permeability involved in apoptotic process | 5.04 |
| 2 | negative regulation of intrinsic apoptotic signaling pathway | 3.14 |
| 2 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 2.14 |
| 2 | positive regulation of apoptotic process | 1.68 |
| MeHg exposure: E+L at 0.1 μM | ||
| Cluster | pathway | EF |
| 0 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 26.46 |
| 1 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 35.41 |
| 1 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 7.97 |
| MeHg exposure: E+L at 1.0 μM | ||
| Cluster | pathway | EF |
| 0 | regulation of apoptotic process | 1.58 |
| 0 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 3.85 |
| 0 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 2.23 |
| 0 | regulation of neuron apoptotic process | 2.02 |
| 0 | negative regulation of apoptotic signaling pathway | 1.90 |
| 0 | positive regulation of apoptotic process | 1.82 |
| apoptotic process | 1.64 | |
| 1 | negative regulation of striated muscle cell apoptotic process | 5.58 |
| 1 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 2.21 |
| 1 | positive regulation of apoptotic process | 2.03 |
| apoptotic process | 1.61 | |
| 2 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 5.25 |
| 2 | positive regulation of apoptotic process | 2.48 |
| 4 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 25.85 |
| 4 | negative regulation of apoptotic process | 1.84 |