TABLE 1.
Characteristics of AIS patients and controls
| Items | Controls (N = 60) | AIS patients (N = 120) | Statistic (t/χ 2/Z) | p value |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Age (years), mean ± SD | 66.0 ± 7.4 | 67.7 ± 10.0 | −1.296 | 0.197 |
| Gender, no. (%) | 2.131 | 0.144 | ||
| Female | 24 (40.0) | 35 (29.2) | ||
| Male | 36 (60.0) | 85 (70.8) | ||
| BMI (kg/m2), mean ± SD | 23.9 ± 2.9 | 23.6 ± 2.2 | 0.815 | 0.416 |
| Current smoke, no. (%) | 29 (48.3) | 51 (42.5) | 0.551 | 0.458 |
| Comorbidities and disease features | ||||
| Hypertension, no. (%) | 44 (73.3) | 100 (83.3) | 2.500 | 0.114 |
| Hyperlipidemia, no. (%) | 29 (48.3) | 56 (46.7) | 0.045 | 0.833 |
| Hyperuricemia, no. (%) | 13 (21.7) | 49 (40.8) | 6.508 | 0.011 |
| Diabetes mellitus, no. (%) | 10 (16.7) | 29 (24.2) | 1.326 | 0.250 |
| CKD, no. (%) | 8 (13.3) | 21 (17.5) | 0.514 | 0.473 |
| No. of risk factors | −2.631 | 0.009 | ||
| 1 | 0 (0.0) | 6 (5.0) | ||
| 2 | 49 (81.7) | 64 (53.3) | ||
| 3 | 9 (15.0) | 32 (26.7) | ||
| 4 | 2 (3.3) | 14 (11.7) | ||
| 5 | 0 (0.0) | 4 (3.3) | ||
| NIHSS score, median (IQR) | – | 9.5 (7.0–12.0) | – | – |
| Inflammatory cytokines | ||||
| TNF‐α (pg/ml), median (IQR) | – | 85.9 (64.1–115.2) | – | – |
| IL‐6 (pg/ml), median (IQR) | – | 45.7 (35.4–62.4) | – | – |
| IL‐10 (pg/ml), median (IQR) | – | 33.6 (24.4–52.4) | – | – |
| IL‐17A (pg/ml), median (IQR) | – | 86.9 (64.6–128.2) | – | – |
Abbreviations: AIS, acute ischemic stroke; BMI, body mass index; CKD, chronic kidney disease; IL‐10, interleukin‐10; IL‐17A, interleukin 17A; IL‐6, interleukin 6; IQR, interquartile range; NIHSS, National Institute Health of Stroke Scale; SD, standard deviation; TNF‐α, tumor necrosis factor alpha.