TABLE 3.
Comparisons of T1DM children with positive and negative ZnT8A
| Positive ZnT8A (n = 37) | Negative ZnT8A (n = 43) | p value | |
|---|---|---|---|
| Age of onset (year) | 4.50 ± 1.66 | 4.26 ± 2.22 | 0.611 |
| Age (year) | 8.42 ± 3.53 | 7.13 ± 3.57 | 0.049 |
| Sex (F:M) | 19:18 | 26:17 | 0.413 |
| BMI (kg/m2) | 15.70 ± 2.12 | 15.61 ± 1.94 | 0.854 |
| DKA (n) (%) | 32 (86.5%) | 28 (65.1%) | 0.028 |
| Glycemia (mmol/L) | 21.66 ± 10.23 | 18.90 ± 10.22 | 0.232 |
| HbA1c (%) | 11.93 ± 2.34 | 10.55 ± 2.90 | 0.024 |
| C‐peptide (pmol/ml) | 0.15 ± 0.12 | 0.14 ± 0.17 | 0.756 |
| CRP (mg/L) | 0.80 (0.20, 2.00) | 0.95 (0.20, 3.17) | 0.727 |
| PCT (μg/mL) | 0.06 (0.04, 0.09) | 0.07 (0.04, 0.17) | 0.258 |
| Microalbuminuria (mg/L) | 6.10 (1.70, 19.02) | 12.60 (3.27, 37.20) | 0.041 |
| T3 (nmol/L) | 1.05 ± 0.52 | 1.35 ± 0.52 | 0.013 |
| T4 (nmol/L) | 86.22 ± 33.29 | 95.31 ± 33.08 | 0.182 |
| TSH (mIU/L) | 1.89 ± 2.18 | 1.76 ± 1.01 | 0.718 |
| GADA (%) | 86.5% | 60.5% | 0.009 |
| Ig (GADA) (μ/ml) | 1.56 ± 0.76 | 1.21 ± 1.12 | 0.105 |
| IA2A (%) | 73.0% | 44.2% | 0.009 |
| Ig (IA2A) (μ/ml) | 1.95 ± 1.12 | 1.91 ± 1.01 | 0.002 |
| Thyroid diseases | |||
| No (%) | 25/37 (67.6) | 31/43 (72.1) | 0.660 |
| Yes (%) | 12/37 (32.4) | 12/43 (27.9) | |
| Family history of thyroid diseases | |||
| No (%) | 34/37 (91.9) | 42/43 (97.7) | 0.504 |
| Yes (%) | 3/37 (8.1) | 1/4 3 (2.3) | |
| Family history of diabetes | |||
| No (%) | 22/37 (59.5) | 30/43 (69.8) | 0.335 |
| Yes (%) | 15/37 (40.5) | 13/43 (30.2) | |
| Peripheral neuropathy | |||
| No (%) | 30/37 (81.1) | 37/42 (86.0) | 0.548 |
| Yes (%) | 7/37 (18.9) | 6/42 (14.0) | |