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. 2022 Jan 13;5(4):e202101315. doi: 10.26508/lsa.202101315

Figure 5. Anti-M2 signaling can be mediated by TNF-independent inflammatory pathways.

Figure 5.

(A, B, C) RNA from wild-type BMDMs left untreated (Ctrl), stimulated with IL4/IL13, IL4/IL13 + TNF (A), IL4/IL13 + IL1b (B) or IL4/IL13 + IL36 (C) was used for qRT-PCR. Data shown are the mean fold-increase compared with the Ctrl group. (D) TnfR1−/− BMDMs were stimulated with IL4/IL13 or IL4/IL13 + TNF over time. RNA was isolated and analyzed for Retnla expression. Data shown are the mean fold-increase of the Ctrl group. All values are means ± SEM; ****P < 0.0001. Statistically significant differences were determined by one-way ANOVA with Tukey correction (A, B, C) or by two-way ANOVA (D). If not indicated otherwise superscripts show statistical significance compared with the control group. n = 3 biological replicates.