Figure S8. Individual assessment of a six-category ordinal scale over time in patients with moderate COVID-19 at baseline, according to the administered dose of plitidepsin.

In patients with moderate COVID-19 at baseline (n = 23 pts), more patients treated at 2.5 mg/d were taken off supplementary oxygen (category 2) and were discharged from the hospital (category 1) by the end of the first week, with respect to other doses (non-statistically significant post hoc finding). The six-point scale was defined as follows (24): 1, discharged or having reached discharge criteria (defined as “clinical recovery”: normalization of pyrexia, respiratory rate <24 breaths per minute, saturation of peripheral oxygen >94% on room air, and relief of cough, all maintained for at least 72 h); 2, hospital admission but not requiring oxygen supplementation; 3, hospital admission for oxygen therapy (but not requiring high-flow or ventilation support); 4, hospital admission for noninvasive ventilation or high-flow oxygen therapy; 5, hospital admission for extracorporeal membrane oxygenation or invasive mechanical ventilation; 6, death. Categories 5 and 6 are not represented in the legend as there were no patients fulfilling the criteria. See also Fig 8B.