Table 4.
Adjusted effects of Na level on 90-day adverse outcomes (death or LT) in the non-cirrhotic patients (n = 1106)
| Number of 90-day adverse outcomes (percentage) | OR,95% CI, p value | OR, 95% CI, p value | OR, 95% CI, p value | OR, 95% CI, p value | |
|---|---|---|---|---|---|
| Model I | Model II | Model III | Model IV | ||
| Na (continuous) | 86 (7.78) | 0.88 (0.84,0.94) < 0.001 | 0.89 (0.84,0.94) < 0.001 | 0.93 (0.88,0.99)0.023 | 0.99 (0.93,1.05)0.659 |
| Na (categorical) | |||||
| (Na level 135–145 mmol/L) | 62 (6.4) | 1 | 1 | 1 | 1 |
| (Na level > 145 mmol/L) | 3 (13.6) | 2.31 (0.67,8.02)0.187 | 2.22 (0.63,7.84)0.215 | 1.98 (0.44,8.89)0.371 | 1.69 (0.36,7.98)0.505 |
| (Na level 120–135 mmol/L) | 21 (18.2) | 3.27 (1.91,5.60) < 0.001 | 2.9 (1.69,5.04) < 0.001 | 2.06 (1.10,3.83)0.024 | 1.47 (0.76,2.81)0.250 |
| p value for trend* | < 0.001 | < 0.001 | 0.023 | 0.207 | |
| Na (Continuous 5 mmol/L decrease) | 0.54 (0.41,0.72) < 0.001 | 0.56 (0.43,0.74) < 0.001 | 0.71 (0.53,0.96)0.023 | 0.93 (0.68,1.28)0.659 | |
| Na (Continuous 10 mmol/L decrease) | 0.29 (0.17,0.51) < 0.001 | 0.32 (0.18,0.55) < 0.001 | 0.51 (0.28,0.91)0.023 | 0.87 (0.46,1.63)0.659 | |
Model I Un-adjusted;
Model II Adjusted for age, sex;
Model III Adjusted for age, sex, HE, ascites, infection;
Model IV Adjusted for age, sex, HE, ascites, infection, TBIL, INR, CR;
CI confidence interval
*Test for trend based on variables containing median value for each group