Table 2.
Summary of hit compounds identified from MMV Pathogen Box and Malaria Box against Theileria infected bovine leucocytes, along with Buparvaquone, a reference drug.
| Compounda | Structure | Mol Wt | Disease Set | ALogPb | IC50 (μM) | CC50 (μM) | TIDc (CC50/IC50) | Ref |
|---|---|---|---|---|---|---|---|---|
| MMV000062 |  |
340.43 | – | 1.75 | 2.97 | >100 | >33.67 | This study |
| MMV560185 |  |
289.38 | – | 3.65 | 3.07 | 34 | 11.07 | This study |
| MMV688372 |  |
401.44 | T. parva Schizonts | 4.43 | 0.61 | 5.3 | 8.69 | Nyagwange et al. (2019) |
| MMV666022 |  |
453.31 | T. annulata schizonts | 5.49 | 0.47 | ND | 11 | Hostettler et al. (2016) |
| MMV666054 |  |
487.76 | T. annulata schizonts | 6.154 | 0.29 | ND | 18 | Hostettler et al. (2016) |
| MMV008212 |  |
280.32 | T. parva Schizonts | 3.59 | 0.78 | >10 | >12 | Nyagwange et al. (2019) |
| MMV689480 (Buparvaquone) |  |
326.43 | T. parva and T. annulata schizonts |
a
Identification code assigned by MMV (www.mmv.org).
b
Lipophilicity index of the compound.
c
Therapeutic Index of the compound.