Table 2.
Association between UFH use and clinical outcomes in patients with sepsis- induced coagulopathy.
| Pre-matched cohort | Control group (n = 1,069) | UFH group (n = 751) | p -value | Effect size (95% CI) | p -value |
|---|---|---|---|---|---|
| 28-day mortalitya | 389 (36.4%) | 128 (17.1%) | <0.001 | HR = 0.361 (0.294, 0.442) | <0.001 |
| Hospital mortalitya | 407 (38.1%) | 148 (19.7%) | <0.001 | HR = 0.414 (0.314, 0.502) | <0.001 |
| Length of ICU stay, daysb | 6.8 (4.2, 12.1) | 11.3 (6.9, 18.1) | <0.001 | β = 4.472 (3.539, 5.406) | <0.001 |
| Length of hospital stay, daysb | 13.2 (8.5, 22.3) | 17.4 (12.2, 27.6) | <0.001 | β = 3.409 (1.966, 4.852) | <0.001 |
| Intracranial hemorrhagec | 50 (4.7%) | 68 (9.1%) | 0.002 | OR = 1.933 (1.317, 2.837) | <0.001 |
| Gastrointestinal bleedingc | 19 (1.8%) | 17 (2.3%) | 0.463 | OR = 1.320 (0.673, 2.589) | 0.419 |
| Post-matched cohort | Control group (n = 652) | UFH group (n = 652) | |||
| 28-day mortality | 246 (37.7%) | 110 (16.9%) | <0.001 | HR = 0.323 (0.258, 0.406) | <0.001 |
| Hospital mortality | 251 (38.5%) | 128 (19.6%) | <0.001 | HR = 0.380 (0.307, 0.472) | <0.001 |
| Length of ICU stay, days | 7.0 (4.5, 13.1) | 11.1 (6.8,17.8) | <0.001 | β = 3.660 (2.495, 4.767) | <0.001 |
| Length of hospital stay, days | 13.2 (7.4, 23.1) | 17.5 (12.6, 26.2) | <0.001 | β = 3.479 (1.849, 5.162) | <0.001 |
| Intracranial hemorrhage | 37 (5.7%) | 54 (8.3%) | 0.065 | OR = 1.480 (0.955, 2.294) | 0.080 |
| Gastrointestinal bleeding | 13 (2.0%) | 14 (2.1%) | 0.814 | OR = 1.094 (0.503, 2.382) | 0.820 |
Values are shown as median (interquartile range) or n (%) unless otherwise indicated.
Cox regression was used for estimating the impact of UFH use on mortality outcomes after adjusting for confounding variables selected based on p-value < 0.05 in univariate analysis and clinical experience. Results were given as hazard ratio (HR) and 95% confidence interval (CI).
Linear regression model was used to evaluate the impact of UFH use on length of stay after adjusting for age, gender, SOFA score and SAPSII. Results were given as beta coefficient and 95% CI.
Bivariate logistic regression was used to assess the associations between UFH use and bleeding complications after adjusting for age, gender, platelet count, INR, PTT, SOFA score and SAPSII. Results were given as odds ratio (OR) and 95% CI.