Table 3.

Pseudoprogression classification.

Category	Localization	Clinical symptoms	Therapy
1a	Increase of known tumor target lesion or manifestation/unmasking of prior unknown tumor	Non-significant	Continue ICI
1b		Significant	Try supportive medication, Stop ICI if no improvement
2a	Distant lesion without underlying tumor manifestation	Non-significant	Continue ICI
2b		Significant	Stop ICI

Side effects and symptoms should be considered “significant” if they correspond to CTCAE grade 3 and 4 or if they correspond to an CTCAE grade 2 that does not resolve with supportive therapy.