Table 1.
Important discoveries of single-cell technology in the evolution of early-stage lung cancer.
| Fields of Lung Cancer | Years | Pathological Type | Conclusions | Reference |
|---|---|---|---|---|
| Tumor Heterogeneity | 2015 | LUAD | Identified intratumoral and intertumoral heterogeneity and the correlation with prognosis | (30) |
| 2017 | SCLC | Proposed a novel mutation profile and expression characteristics of SCLC | (31) | |
| 2020 | LUAD | Detected heterogeneity at the molecular level in each tumor and stromal cells of GGN more effectively | (32) | |
| 2021 | LUAD | Characterized the heterogenetic of tumor cells, immune cells, and stromal cells in SSN lesions | (33) | |
| Evolution and Metastasis | 2014 | NSCLC | Detected the differential expression in metastasis-associated cancer initiation cells | (34) |
| 2020 | LUAD | Revealed the progression of lung adenocarcinoma mainly depends on tumor cell reprogramming | (35) | |
| 2020 | LUAD | Discovered a cluster of tumor cells with high plasticity and the potential to transform into different states | (36) | |
| 2021 | LUAD | Analyzed unravel cell populations, states, and phenotypes in the spatial and ecologic evolution | (37) | |
| Tumor Metabolic | 2017 | LUAD | Found a new metabolic phenotype of lung cancer and provide a theoretical framework | (38) |
| 2019 | LUAD | Analyzed different expressed genes of single malignant cells with different metabolic phenotypes | (39) | |
| Lung Cancer Treatment | 2015 | LUAD (cell line) | Revealed different expression patterns of individual cells induced by molecular targeted drug therapy resistance | (40) |
| 2021 | LUAD | Characterized the different tumor microenvironment and provided prognostic information | (41) | |
| Tumor Microenvironment | 2017 | LUAD | Analyzed the early immune cells, especially the innate immune cells and their molecular profiles | (42) |
| 2018 | NSCLC | Showed the landscape of stroma and immune cells of NSCLC | (43) | |
| 2018 | NSCLC | Explored the heterogeneity and characteristics of T cells in TME | (44) | |
| 2020 | NSCLC | Reveals the diversity of B cells in the early stage of non-small cell lung cancer | (45) | |
| 2021 | NSCLC | Verified the enrichment of different macrophage subtypes in lung cancer | (46) | |
| 2021 | LUAD | Characterize shifts in the TME from early to advanced lung cancer | (47) |
LUAD, lung cancer adenocarcinoma; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer; GGN, ground glass nodule; SSN, subsolid nodule; CNV, copy number variation.