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. 2022 Jan 7;39:100927. doi: 10.1016/j.gore.2022.100927

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© 2022 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Overview of proposed mechanisms underlying beneficial effects of exercise on CIPN. Several biological mechanisms have been proposed to explain the relationships between exercise, CIPN, and sleep. In general, exercise counteracts the deleterious effects of chemotherapy on the nervous system by reducing inflammation, promoting brain neuroplasticity, and enhancing pain modulation pathways. Abbreviations: 5-HT, 5-hydroxytryptamine (serotonin); BDNF, brain-derived neurotrophic factor; GABA, gamma-aminobutyric acid; GDNF, glial-derived neurotrophic factor; IL-1RA, interleukin 1 receptor antagonist; IL-1B, interleukin 1Beta; IL-6, interleukin 6; IL-8, interleukin 8; IL-10, interleukin 10, mIL-6, myokine ROS, reactive oxygen species; TNF-A, tumor necrosis factor-Alpha.