. 2021 Sep 27;61(1):1–16. doi: 10.1007/s40262-021-01073-3

Table 1.

Transactivational activity of vilaprisan

	Antagonistic activity IC₅₀ (nmol/L)
Vilaprisan (mean ± SD)	0.09 ± 0.0005	0.095 ± 0.001	957 ± 42	47 ± 32	No effect	No effect
Reference compound (mean ± SD)	Mifepristone 0.023 ± 0.02	Mifepristone 0.02 ± 0.008	Mifepristone 6 ± 0.5	OH-flutamide 21 ± 9	Fulvestrant 2.0 ± 0.6	Fulvestrant 2.7 ± 0.7

Antagonistic activity IC₅₀ (nmol/L)

Progesterone receptor A

Progesterone receptor B

Glucocorticoid receptor

Androgen receptor

Estrogen receptor α

Estrogen receptor β

Vilaprisan (mean ± SD)

0.09 ± 0.0005

0.095 ± 0.001

957 ± 42

47 ± 32

No effect

Reference compound (mean ± SD)

Mifepristone

0.023 ± 0.02

Mifepristone

0.02 ± 0.008

Mifepristone

6 ± 0.5

OH-flutamide

21 ± 9

Fulvestrant

2.0 ± 0.6

Fulvestrant

2.7 ± 0.7

IC₅₀ half maximal inhibitory concentration, OH-flutamide hydroxyflutamide, SD standard deviation [8]