Table 2.
Results of 1 year of TREC Screening (10 October 2019 to 9 October 2020).
| Case | GA* | Sex | Age+ | TREC# (copies/µL) | ALC^ (x106/L) | CD3+ (cells/µL) (%) | CD3+/CD4+ CD45RA+ | Diagnosis | BCG vaccination | Resolution of TCL (age)/follow-up duration |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 26+2 | M | 3 d | 10 | 2.33 | – | – | Very Premature with pulmonary hypertension, severe BPD, post-natal CMV disease | Yes, at 1y 4m old, after TCL resolved | Yes (6 months)/22 months |
| 13 d | 14 | 1.82 | – | – | ||||||
| 70 d | 12 | – | – | – | ||||||
| 78 d | – | – | 633 (36%) | 87.4% | ||||||
| 16 m | – | – | 2157 (60%) | 82.8% | ||||||
| 2 | 27+1 | M | 2 d | 5 | 0.75 | – | – | Very Premature with severe IUGR, Pulmonary hypertension with severe cystic BPD | No, died at 5 months old | Incomplete, died before resolution/5 months |
| 12 d | – | 3.69 | – | – | ||||||
| 14 d | 10 | - | – | – | ||||||
| 29 d | 11 | 3.14 | – | – | ||||||
| 76 d | – | – | 1773 (54%) | 94.0% | ||||||
| 3 | 29+1 | F | 5 d | 6 | 0.60 | – | – | Very Premature ELBW Trisomy 21 with SGA, imperforate anus s/p colostomy, with chylothorax | No, died at 2 months old | Incomplete, died before resolution/2 months |
| 15 d | 7 | 0.50 | – | – | ||||||
| 28 d | 10 | 0.94 | 1265 (73%) | 88.7% | ||||||
| 43 d | 11 | 1.29 | 893 (66%) | – | ||||||
| 57 d | – | 2.23 | 2096 (53%) | – | ||||||
| 4 | 32+2 | M | 6 d | 7 | 0.47 | – | – | Premature Trisomy 21 with SGA, fetal hydrops, ileal atresia s/p stoma, GI losses | Yes, at 42 days old, after TCL resolved | Yes (29 days)/22 months |
| 14 d | 14 | 0.96 | – | – | ||||||
| 29 d | 50 | 3.04 | 2149 (65%) | 82.4% | ||||||
| 5 | 37+1 | M | 2 d | 7 | 0.00 | – | – | Sepsis-related secondary TCL (E Coli bacteremia, meningitis) | Yes, at 21 days old after TCL resolved | Yes (Likely by 7 days)/19 months |
| 7 d | – | 4.86 | – | – | ||||||
| 14 d | 89, 97 | – | declined | |||||||
| 1 y | – | 5.07 | 2724 (66%) | – | ||||||
| 6 | 37+6 | F | 2 d | 15 | – | – | – | Persistent idiopathic TCL of unclear cause | Yes, at 2 days old | No/12 months |
| 11 d | 31,25, 51 | 3.15 | clotted | – | ||||||
| 18 d | – | – | 1043 (53%) | 86.3% | ||||||
| 6 m | 11 | 2.64 | 881 (39%) | – | ||||||
| 10 m | 12 | 1.82 | 683 (44%) | – | ||||||
| 7 | 38+3 | F | 2 d | IC | – | – | – | Transient idiopathic TCL | Yes, at 1 day old | Yes (17 days)/13 months |
| 10 d | 14 | – | – | – | ||||||
| 17d | – | 5.02 | 2090 (47%) | 80.0% | ||||||
| 8 | 38+4 | M | 3 d | 6 | – | – | – | Transient idiopathic TCL | Yes, at 3 days old | Yes (13 days)/20 months |
| 13 d | 92, 75 | 7.11 | 5525 (73%) | 73.6% | ||||||
| 9 | 39+0 | F | 1 d | 12 | – | – | Transient idiopathic TCL | Yes, at 1 day old | Yes (9 days)/22 months | |
| 9 d | – | 7.77 | 3957 (81%) | 72.4% | ||||||
| 10 | 39+1 | M | 1 d | – | 2.17 | – | – | 22q11 Syndrome with transient TCL | Yes, at 6 days old | Yes (19 days)/10 months |
| 3 d | IC | – | – | – | ||||||
| 12 d | 7 | – | – | – | ||||||
| 19 d | – | 3.58 | 2248 (51%) | 86.0% | ||||||
| 11 | 40+0 | F | 3 d | 7 | – | – | – | Sepsis-related secondary TCL (low platelets, culture negative) | Yes, at 3 days old | Yes (7 days)/14 months |
| 7 d | 94 | 5.83 | 3093 (67%) | 71.1% | ||||||
| 12 | 40+0 | F | 2 d | 1 | – | – | – | Initial severe TCL, Transient idiopathic TCL | Yes, 1 day old | Yes (6.5 months)/13 months |
| 8 d | – | 1.52 | 124 (12%) | 61.3% | ||||||
| 14 d | – | – | 210 (15%) | – | ||||||
| 62 d | IC | – | 345 (21%) | – | ||||||
| 4 m | 120 | – | 773 (20%) | 64.6% | ||||||
| 6 m | – | 4.59 | 2115 (43%) | 74.6% | ||||||
| 9 m | – | 5.42 | 2900 (60%) | – | ||||||
| 13 | 40+1 | F | 1 d | 15 | – | – | – | Transient idiopathic TCL | Yes, at 1 day old | Yes (6 months)/17 months |
| 11 d | 12 | – | – | – | ||||||
| 17 d | – | 4.29 | 1054 (69%) | 65.8% | ||||||
| 6 m | – | 3.11 | 2539 (45%) | – |
GA*: Gestational Age; Age+ in d, days; m, months; y, year; TREC #: T-cell Receptor Excision Circle number, copies/μL, ALC^ Absolute lymphocyte count, x 106/L, used as surrogate marker for lymphopenia; CD3+: CD3+ T cells absolute number and percentage; CD3+ or CD4+CD45RA+ naïve T cells as a percentage of total CD3+ or CD4+ T cells; TCL, T cell lymphopenia; ELBW, extremely low birth weight; SGA, small for gestational age; IUGR, intrauterine growth restriction; s/p, status post; GI, Gastrointestinal; BPD, bronchopulmonary dysplasia; IC, inconclusive or poor sample.