Table 2.
Cox regression analysis of the clinical variables, and overall survival in CGGA cohorts.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI for HR) | P value | HR (95% CI for HR) | P value | |
| FCGBP PRS_type |
1 (1-1) 1 (0.9-1.2) |
0.00*
0.56 |
1.01 (1.01-1.02) 0.78 (0.43-1.41) |
0.00*
0.41 |
| Histology | 1 (1-1.1) | 0.04* | 1.11 (0.95-1.28) | 0.18 |
| Grade | 1.5 (1.3-1.7) | 0.00* | 1.32 (1.04-1.67) | 0.02* |
| Gender | 0.99 (0.83-1.2) | 0.95 | 1.04 (0.84-1.3) | 0.69 |
| Age | 1 (1-1) | 0.01* | 1 (0.99-1.01) | 0.64 |
| OS | 1 (1-1) | 0.03 * | 1 (1-1) | 0.00* |
| Radio | 1.1 (0.87-1.4) | 0.41 | 1.09 (0.82-1.45) | 0.54 |
| Chemo | 1.3 (1-1.6) | 0.03* | 0.92 (0.7-1.2) | 0.53 |
| IDH_mutation | 1.8 (1.5-2.2) | 0.00* | 1.46 (1.11-1.93) | 0.01* |
| 1p19q_codeletion | 3.8 (2.5-5.7) | 0.00* | 4.68 (2.45-8.91) | 0.00* |
| MGMTp_methylation | 0.91 (0.75-1.1) | 0.36 | 0.87 (0.7-1.08) | 0.22 |
HR, hazard ratio; CI, confidence interval; CGGA, Chinese Glioma Genome Atlas; IDH, isocitrate dehydrogenase; MGMTp, O6-methylguanine-DNA methyltransferase promoter. “*” and Bold values indicates P-value < 0.05.