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. 2022 Jan 3;11:803974. doi: 10.3389/fonc.2021.803974

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Copyright © 2022 Yang, Meng and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Section (A) (green background) indicates the origins of cancer-associated fibroblasts (CAFs) including bone marrow derived mesenchymal stem cells, cancer stem cells, endothelial cells (through endothelial mesenchymal transition: EMT), normal fibroblasts; Section (B) (blue background) indicates the effect of CAFs on gastric cancer stem cells (GCSCs) including angiogenesis and EMT; Section (C) (grey background) indicates the effect of (GCSCs) on gastric cancer cells including proliferation, invasion and metastasis.