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. 2022 Jan 3;12:809244. doi: 10.3389/fimmu.2021.809244

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Copyright © 2022 Mistry, Barmania, Mellet, Peta, Strydom, Viljoen, James, Gordon and Pepper

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Currently circulating SARS-CoV-2 variants of concern and their receptor binding domain (RBD) amino acid substitutions of interest to virulence and immune evasion. The N501Y substitution is common to the Alpha, Beta, Gamma and Omicron variant strains. The E484K/Q/A and K417T/N substitutions are present in the Beta, Gamma and Omicron strains, while the L452R substitution is unique to the Delta variant. Image created by PM using BioRender (https://biorender.com/).