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. 2021 Dec 20;21(1):100189. doi: 10.1016/j.mcpro.2021.100189

Fig. 4.

Fig. 4

MOMENTA analysis of metabolic variation across diverse cancer cell lines.A, workflow for CCLE proteomic profiling data processing and MOMENTA analysis. B, enrichment results for top Neighborhood pathways (Adj. p Value < 0.01) for enrichment based on global profile PC1. C, distribution of tissue derived cancer cell lines across PC1. D, relative intensity of glutamate metabolism pathway metabolites in CCLE for highlighted cancer cell types, with p Values for comparison between Breast and Pancreas based on Kruskal–Wallis test. E, relative intensity of metabolites in tumor and normal tissue samples for both Breast (BRCA) and Pancreas (PAAD) cancers showing corresponding p Values (t test). CCLE, Cancer Cell Line Encyclopedia; MOMENTA, multiomic metabolic enrichment network analysis.