Table 1.
Variables | TCGA cohort | Radiogenomic Cohort | Validation cohort | |||
---|---|---|---|---|---|---|
n = 335 | n = 120 | n = 155 | ||||
N | % | N | % | N | % | |
Age (years) | ||||||
18-60 | 194 | 57.9 | 80 | 66.7 | 137 | 88.4 |
>60 | 141 | 42.1 | 40 | 33.3 | 18 | 11.6 |
Laterality | ||||||
Left | 165 | 49.3 | 61 | 50.8 | 77 | 49.7 |
Right | 170 | 50.7 | 59 | 49.2 | 78 | 50.3 |
Race | ||||||
White | 216 | 64.5 | 97 | 80.8 | 143 | 92.3 |
Black or African American | 70 | 20.9 | 22 | 18.3 | 4 | 2.6 |
Asian | 21 | 6.3 | 1 | 0.8 | 8 | 5.2 |
Other | 28 | 8.4 | / | / | / | / |
Status | ||||||
Alive | 286 | 85.4 | 117 | 97.5 | 132 | 85.2 |
Dead | 49 | 14.6 | 3 | 0.5 | 21 | 13.5 |
Lost | 0 | 0 | 0 | 0 | 2 | 1.3 |
OS(years) | ||||||
≤1 | 50 | 14.9 | 6 | 5.0 | 5 | 3.2 |
>1 ≤3 | 151 | 45.1 | 50 | 41.7 | 21 | 13.6 |
>3 ≤5 | 58 | 17.3 | 31 | 25.8 | 102 | 65.8 |
>5years | 70 | 20.9 | 30 | 25.0 | 27 | 17.4 |
Unknown | 6 | 1.8 | 3 | 2.5 | 0 | 0 |
Depth of invasion | ||||||
pT1 | 70 | 20.9 | 48 | 40.0 | / | / |
pT2 | 220 | 65.7 | 66 | 55.0 | / | / |
pT3 | 33 | 9.9 | 6 | 5.0 | / | / |
pT4 | 12 | 3.6 | 0 | 0 | / | / |
Lymph node metastasis | ||||||
pN0 | 166 | 49.6 | 63 | 52.5 | / | / |
pN1 | 107 | 31.9 | 41 | 34.2 | / | / |
pN2 | 36 | 10.7 | 9 | 7.5 | / | / |
pN3 | 21 | 6.3 | 6 | 5.0 | / | / |
pNx | 5 | 1.5 | 1 | 0.8 | / | / |
Metastasis | ||||||
pM0 | 277 | 82.7 | 94 | 78.3 | / | / |
pM1 | 6 | 1.8 | 0 | 0 | / | / |
pMx | 52 | 15.5 | 26 | 21.7 | / | / |
Stage | ||||||
I | 49 | 14.6 | 28 | 23.3 | / | / |
II | 206 | 61.5 | 76 | 63.4 | / | / |
III | 69 | 20.6 | 16 | 13.3 | / | / |
IV | 6 | 1.8 | 0 | 0 | / | / |
Unknown | 5 | 1.5 | 0 | 0 | / | / |
Estrogen receptor status | ||||||
Positive | 206 | 61.5 | 99 | 82.5 | 88 | 56.8 |
Negative | 116 | 34.6 | 21 | 17.5 | 65 | 41.9 |
Indeterminate | 0 | 0 | 0 | 0 | 0 | 0 |
Unknown | 13 | 3.9 | 0 | 0 | 2 | 1.3 |
Progesterone receptor status | ||||||
Positive | 173 | 51.6 | 88 | 73.3 | 74 | 47.7 |
Negative | 148 | 44.2 | 32 | 26.7 | 79 | 51.0 |
Indeterminate | 1 | 0.3 | 0 | 0 | 0 | 0 |
Unknown | 13 | 3.9 | 0 | 0 | 2 | 1.3 |
Human epidermal growth factor receptor 2 status | ||||||
Positive | 60 | 17.9 | 13 | 10.8 | 47 | 30.3 |
Negative | 184 | 54.9 | 62 | 51.7 | 105 | 67.7 |
Indeterminate | 46 | 13.7 | 26 | 21.7 | 0 | 0 |
Unknown | 45 | 13.4 | 19 | 15.8 | 3 | 2.0 |
Neoadjuvant chemotherapy | ||||||
YES | 316 | 94.3 | 1 | 0.8 | 153 | 98.7 |
NO | 0 | 0 | 119 | 99.2 | 2 | 1.3 |
Unknown | 19 | 5.7 | 0 | 0 | 0 | 0 |