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. 2022 Jan 3;12:758267. doi: 10.3389/fimmu.2021.758267

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Copyright © 2022 Sharma, Banerjee, Krueger and Blois

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum-based proposed animal model of GDM. Schematic presentation describes a strategy for a humanized mouse model of gestational diabetes mellitus mimicking metabolic and immune pathologies of the human pregnancy complication. It is a human serum-based model of GDM. Analysis of serum, placental tissue, fetal weight and size, placental insulin resistance signaling, and peripheral and uterine immune profiles is expected to recapitulate all the features associated with GDM.