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Schematic presentation of a tetraspanin. The model depicts the conserved structural features of tetraspanins. EC1 and EC2 represent the short and large extracellular domains, respectively. Transmembrane domains TM1–TM4 and the CCG motif along with disulfide bonds between two pairs of cysteine residues in EC2 are shown. N- and C-termini as well as the intracellular loop (IL) are located in the cytosol.
