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. 2022 Jan 3;14:801882. doi: 10.3389/fnmol.2021.801882

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Copyright © 2022 Becic, Leifeld, Shaukat and Hollmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall structure of a tetraspanin (A). Helices A–E are indicated in the EC2 domain between TM3 and TM4. Helices A, B, and E represent conserved regions, while helices C–D are variable among tetraspanins. Superposition of all previously resolved structures of tetraspanins (B). Shown is the overlay of Tspan25 (pdb model 6WVG in yellow) with Tspan28 (pdb model 5TCX in blue) and of Tspan25 (yellow) with Tspan29 (pdb model 6K4J in magenta) as well as of Tspan28 (blue) with Tspan29 (magenta).